Osteoarthritis: Could research ers have found the key to prevention? Published in February 2018, a study by Honor Whiteman may have revealed a possible new prevention and treatment strategy for osteoarthritis which is one of the most common and debilitating age-related.
By boosting the levels of FoxO proteins, researchers believe that it might be possible to treat osteoarthritis or even stop the disease from developing.
Osteoarthritis is also referred to as degenerative joint disease.
The condition is characterized by a breakdown of cartilage which is the tissue that cushions the joints of the bones. Osteoarthritis most commonly affects the knee, hip, and hand joints.
The reduced production of lubricin was linked to a reduction in healthy cells in the “superficial zone,” which is a layer of cartilage in the knee joint.
The absence of FoxO proteins in the joint cartilage leads to an increase in inflammation and a decrease in autophagy, meaning that cells are unable to repair any damage.
By increasing FoxO expression in cells taken from people with osteoarthritis, the researchers were able to normalize the expression of genes associated with inflammation and autophagy, and the production of lubricin was also restored.
“Drugs that boost the expression and activity of FoxO could be a strategy for preventing and treating osteoarthritis.”